Summary of Science,
September 2008.
You can find all the Science summaries in web format at:
http://sullydog.com/sullysites/jclubscience/
Unlike the JCBFM journal club, ONLY RELEVANT ARTICLES are
listed. My relevance assessment is entirely implicit and is designated with
regard to work we are doing or contemplating RIGHT NOW.
In Oct 2008, I had to scrape the bottom of th barrelt:
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*1. Internally Generated Cell Assembly Sequences in the Rat
Hippocampus. Eva Pastalkova, et al.
Sullysummary:
This data is purported to show that the hippocampus is not only repsonsible for
pickling new memories, but also for pulling old ones out of the pickle jar, and
thereby very important for spatial-temporal navigation. At
least in rats.
Relevance: Medium
Link (PDF):
http://www.sciencemag.org/cgi/reprint/321/5894/1322.pdf
Link (Review,
PDF): http://www.sciencemag.org/cgi/reprint/321/5894/1280b.pdf
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*2. Is the LHC a
Doomsday Machine?
Sullysummary:
Predictably, people who don't have anything remotely like a clue are Freaking
Out about the Large Hadron Collider.
Relevance:
Completely irrelevant, but fun.
Link (PDF):
http://www.sciencemag.org/cgi/reprint/321/5894/1291.pdf
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*3. Scientists Under Siege. Deborah C. Runkle.
Sullysummary: A
review of "The Animal Research War." Sobering.
This is why we live in a secure building.
Relevance:
Medium.
Link (PDF):
http://www.sciencemag.org/cgi/reprint/321/5895/1448a.pdf
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*4. Activation of
Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart. Che-Hong Chen, et al.
Sullysummary: A
proteomic search identified mitochondrial aldehyde dehydrogenase 2 as a possibly
cardioprotective enzyme. It appears to be responsble for the metabolism of, or
inhibition of formation of, potentially cytotoxic aldehydes.
Relevance: Low-Medium.
Link (PDF):
http://www.sciencemag.org/cgi/reprint/321/5895/1493.pdf
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*5. Fluorous Tags
Unstick Messy Chemical Biology Problems. Dennis P. Curran.
Sullysummary:
Using teflon to unmix messy biochemical mixtures. How
well something like this might translate to our own work is unclear to me, but
the technique is very intriguing.
Relevance:
Low-Medium
Link (PDF):
http://www.sciencemag.org/cgi/reprint/321/5896/1645.pdf
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END SUMMARY.