1. What is Brain Ischemia? - Why, ischemia of the brain, of course.
• Two Flavors of Ischemia - Focal and global.
• Scope of the Problem - Big. Really big.
• Ischemia Cocks the Hammer, Reperfusion Pulls the Trigger.
2. Bad Things Happen in Ischemia  
3. Worse Things Happen in Reperfusion
• The Four Horsemen - of the Brainocalypse.
• Oxidative Stress - It's stressful. AND it's oxidative. Go figure.
• Stress from WHAT? -Causes of oxidative stress
• ROS: The Horror Continues. -Lipid Peroxidation
• Son of Superoxide -Peroxynitrite
• More Superoxide Madness - peroxide and hydroxyl radical
• A Free Radical Bestiary - a veritable zoo of radical species
• Calpain
• Who is This Calpain Dude? - A good enzyme gone bad.
• It's Even Worse Than That - Calpain autoproteolysis and activation
• Kalpain's Krazy Killing Karnival - Calpain targets
• Protein Synthesis Inhibition
• Let's Review, Shall We? - The central dogma, transcription and translation
• The Long March - Looking for the cause of protein synthesis inhibition
• Translashun and the Shun-ettes! - a review of translation initiation
• Well, THAT's suspicious behavior - eIF2α (P) in reperfusion
• 2α Kinases- the usual suspects
• PERK up! - The guilty kinase and its MO
• Apoptosis
• The Death Spectrum - apoptosis vs. necrosis
• Capt Kirk and Stroke - elements of the apoptosis process
• Elegance and Death - lessons from C. Elegans
• Rudy's Wormy Jeans - mammalian ced homologs
• The Bomb - introducing caspases
• The Targets - caspase substrates
• What a CAD - caspase-activated DNAase
• Caspase Flavors - initiators, executioners, and others
• The Outer Trigger - extrinsic apoptosis
• The Inner Trigger - intrinsic apoptosis
• The Abort Code - introducing the Bcl-2 family
• Think You Can Hold Me, Sherrif? - balancing "good" and "bad" Bcl-2 interactions
• Gonna Be a Shoot-Out! - Bcl-2 interactions after ischemia
• Showdown at the Mito Corral - example of Bcl-2 interactions mediating apoptosis
• Ruled a Suicide? - The Apoptosis-Necrosis "controversy."
• You've Been Had! - Gotcha.
• Neuroptocrosis? - Good a word as any.
• Chaos Theory Fries Your Brain - But not in a good way.
• A Little Cell Death Humor - Note the apoptotic bodies.
• The Silver Lining - Every Cloud has one.
4. Take Your Medicine - Time for a little therapy.
• Make Your Medicine - We are doctors, after all.
• Your Homework: Cure Stroke - no cheating.
• Nip It in the Bud - Blocking excitotoxicity.
• Target: ROS - Defeating the radicals.
• Target: Calpain - Shutting down Pac-Man.
• Target: Protein Synthesis - For better or worse.
• Turn Me On: Insulin and eIF2
• Target: Apoptosis - Talking down suicidal neurons.                                    
• Growth Factors are Goooood! - So much to live for.   
• Signal for Survival - How growth factors work.                                   
• Multiple Aktions - A linchpin of survival signaling.                         
• A Dose of Reality - Before we get too excited...
• No Silver Bullets - For brain ischemia. Werewolves are a different syllabus.  
• Chill Out - Talk about a brain freeze.  
• You Said No Silver Bullets! - That's right. I did. Back off.                      
• You Can Do Combinations! - Herewith, the future.
5. Further Reading and Exercises. I know you can't wait.

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