..AND HIS TRUSTY BLADE FUBARING, SWORD OF MAYHEM
We have seen that, during early
ischemia, calcium floods into the cell from the interstitium and
endoplasmic reticulum due to the loss of ATP and cellular pumps. And we
have seen that this flood of calcium triggers lipolysis and the vicious
sequelae of oxidative stress. But the damage of calcium flux goes
beyond all that. The surge in calcium transforms the protease calpain from an essential player in the remodeling of neurites and synapses to a badass berserker with an attitude.