..TRAINING HIS PERKY BOW ON YOUR HAPLESS RIBOSOMES.
We now come to a problem that has consumed the
lion's share of this lab's attention over the last twenty years. It has
long been known that ischemia results in a prompt cessation of protein
synthesis throughout the brain, and that neurons that go on to die
never recover their ability to incorporate amino acids into new
protein, even though ATP levels return to near-normal soon after
reperfusion. This phenomenon was first reported by Kleihues and Hossman in 1971.
Nearly forty years later, although we've learned a lot, we're still
trying to pin down exactly what's causing it.