Protein Synthesis Inhibition...

..TRAINING HIS PERKY BOW ON YOUR HAPLESS RIBOSOMES.

We now come to a problem that has consumed the lion's share of this lab's attention over the last twenty years. It has long been known that ischemia results in a prompt cessation of protein synthesis throughout the brain, and that neurons that go on to die never recover their ability to incorporate amino acids into new protein, even though ATP levels return to near-normal soon after reperfusion. This phenomenon was first reported by Kleihues and Hossman in 1971. Nearly forty years later, although we've learned a lot, we're still trying to pin down exactly what's causing it.