You Said No Silver Bullets!

That's right, I did--and I said it to underscore the argument that single drug therapy will never work. But here's the deal: hypothermia is not single therapy!

Like insulin, hypothermia has multiple salutary effects. It has been shown to:

  1. Induce pro-survival signaling processes--including activation of Akt!
  2. Inhibit cytochrome c release from mitochondria!
  3. Decrease free radical production and propagation!
  4.  Decrease lipolysis!
  5.  Change glutamate receptor composition and activation in ways that are good for you!

That's one terrific therapeutic package…not single therapy at all. Cool.