The classical model for apoptosis
is the worm C. Elegans. This is a simple organism that produces exactly
1090 cells during development, of which exactly 131 undergo
apoptosis. Investigation of this worm has demonstrated five families of genes
that regulate apoptosis in C. Elegans.
- Genes that trigger apoptosis, including the C.
Elegans death (ced) gene ced-4.
- Genes involved in execution of apoptosis,
- Genes required for the engulfement of the dead
- Genes required for disposal of the cellular
- A single gene (ced-9) that suppresses
Worm of Doom. C. Elegans, perhaps the most-studied worm in the world.